NFL Schedule - 2025 (Team: BUF)
| Week | Weekday | Date | EST | Away | Score | Home | Score |
|---|---|---|---|---|---|---|---|
| Week 1 | Sunday | 2025-09-07 | 20:20 |  BAL | NA |  BUF | NA |
| Week 2 | Sunday | 2025-09-14 | 13:00 | BUF | NA |  NYJ | NA |
| Week 3 | Thursday | 2025-09-18 | 20:15 |  MIA | NA | BUF | NA |
| Week 4 | Sunday | 2025-09-28 | 13:00 |  NO | NA | BUF | NA |
| Week 5 | Sunday | 2025-10-05 | 20:20 |  NE | NA | BUF | NA |
| Week 6 | Monday | 2025-10-13 | 19:15 | BUF | NA |  ATL | NA |
| Week 8 | Sunday | 2025-10-26 | 13:00 | BUF | NA |  CAR | NA |
| Week 9 | Sunday | 2025-11-02 | 16:25 |  KC | NA | BUF | NA |
| Week 10 | Sunday | 2025-11-09 | 13:00 | BUF | NA | MIA | NA |
| Week 11 | Sunday | 2025-11-16 | 13:00 |  TB | NA | BUF | NA |
| Week 12 | Thursday | 2025-11-20 | 20:15 | BUF | NA |  HOU | NA |
| Week 13 | Sunday | 2025-11-30 | 16:25 | BUF | NA |  PIT | NA |
| Week 14 | Sunday | 2025-12-07 | 16:25 |  CIN | NA | BUF | NA |
| Week 15 | Sunday | 2025-12-14 | 13:00 | BUF | NA | NE | NA |
| Week 16 | Sunday | 2025-12-21 | 13:00 | BUF | NA |  CLE | NA |
| Week 17 | Sunday | 2025-12-28 | 16:25 |  PHI | NA | BUF | NA |
| Week 18 | Sunday | 2026-01-04 | 13:00 | NYJ | NA | BUF | NA |
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