NFL Schedule - 2025 (Team: SF)
| Week | Weekday | Date | EST | Away | Score | Home | Score |
|---|---|---|---|---|---|---|---|
| Week 1 | Sunday | 2025-09-07 | 16:05 |  SF | NA |  SEA | NA |
| Week 2 | Sunday | 2025-09-14 | 13:00 | SF | NA |  NO | NA |
| Week 3 | Sunday | 2025-09-21 | 16:25 |  ARI | NA | SF | NA |
| Week 4 | Sunday | 2025-09-28 | 16:05 |  JAX | NA | SF | NA |
| Week 5 | Thursday | 2025-10-02 | 20:15 | SF | NA |  LA | NA |
| Week 6 | Sunday | 2025-10-12 | 13:00 | SF | NA |  TB | NA |
| Week 7 | Sunday | 2025-10-19 | 20:20 |  ATL | NA | SF | NA |
| Week 8 | Sunday | 2025-10-26 | 13:00 | SF | NA |  HOU | NA |
| Week 9 | Sunday | 2025-11-02 | 13:00 | SF | NA |  NYG | NA |
| Week 10 | Sunday | 2025-11-09 | 16:25 | LA | NA | SF | NA |
| Week 11 | Sunday | 2025-11-16 | 16:05 | SF | NA | ARI | NA |
| Week 12 | Monday | 2025-11-24 | 20:15 |  CAR | NA | SF | NA |
| Week 13 | Sunday | 2025-11-30 | 13:00 | SF | NA |  CLE | NA |
| Week 15 | Sunday | 2025-12-14 | 16:25 |  TEN | NA | SF | NA |
| Week 16 | Monday | 2025-12-22 | 20:15 | SF | NA |  IND | NA |
| Week 17 | Sunday | 2025-12-28 | 20:20 |  CHI | NA | SF | NA |
| Week 18 | Sunday | 2026-01-04 | 13:00 | SEA | NA | SF | NA |
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