Desmond Little is a defensive end from Prichard, Alabama.
He attended Vigor High School and played at LSU before transferring to UAB. He signed with Indianapolis as an undrafted rookie in 2025.
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Little played at LSU before joining UAB for the 2023 season.
He appeared in 11 games with seven starts in 2023, recording 29 tackles, 7.5 tackles for loss and a team-leading 5.5 sacks. In 2024, he started all 12 games at edge rusher and finished with 41 tackles, 10 tackles for loss and six sacks.
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Indianapolis signed Little as an undrafted free agent on May 9, 2025.
The Colts' official transaction log lists him among their rookie signings as a defensive end.
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Little spent the 2025 offseason and training camp with Indianapolis.
The Colts waived him August 26, 2025. In January 2026, the UFL announced Birmingham's selection of Little through its regional college allocation process.
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Little earned first-team All-American Athletic Conference honors in 2024.
His senior season included two sacks and 3.5 tackles for loss against Connecticut.
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