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Entering Week 2 outlooks from MyFootballToolbox Power Rankings. Based on the entering-Week-2 rankings following completed Week 1. Confidence points indicate an order, not a win probability or guarantee. Expert picks can differ from the market favorite.

16POINTS

Expert pick: San Francisco 49ers

Sun Sep 20 - 4:25 PM ET

San Francisco 49ers favored by 12.5 points (reference line)

Miami Dolphins

Designated away · Power Rank #32

Consensus average: 31.25. Miami's outlook remains developmental, with promising rookie contributions offering encouragement. Consistent improvement across a thin roster matters more than drawing sweeping conclusions from one loss.

San Francisco 49ers

Designated home · Power Rank #9

Consensus average: 7.75. San Francisco made a convincing opening statement. Keeping its veteran defensive core healthy remains essential to turning that performance into sustained contention.

15POINTS

Expert pick: Baltimore Ravens

Sun Sep 20 - 1:00 PM ET

Baltimore Ravens favored by 8.5 points (reference line)

New Orleans Saints

Designated away · Power Rank #20

Consensus average: 19.75. New Orleans showed enough offensive promise to remain encouraged. Starting faster is the immediate challenge; another late surge may not erase an early deficit.

Baltimore Ravens

Designated home · Power Rank #4

Consensus average: 5.25. Baltimore's balanced attack looks comfortable under its new staff. Sustaining that efficiency while tightening run defense would strengthen the case for an extended winning start.

14POINTS

Expert pick: Kansas City Chiefs

Sun Sep 20 - 8:20 PM ET

Kansas City Chiefs favored by 6.5 points (reference line)

Indianapolis Colts

Designated away · Power Rank #26

Consensus average: 25.50. Indianapolis needs improvement from its quarterback and overwhelmed defense. Week 2 tests whether both units can regain stability together.

Kansas City Chiefs

Designated home · Power Rank #5

Consensus average: 6.25. A productive running game and strong defense give Kansas City more ways to win. Maintaining that support eases the burden on Patrick Mahomes.

13POINTS

Expert pick: Philadelphia Eagles

Sun Sep 20 - 1:00 PM ET

Philadelphia Eagles favored by 7 points (reference line)

Philadelphia Eagles

Designated away · Power Rank #11

Consensus average: 11.00. Philadelphia escaped its opener without resolving concerns about offensive rhythm. More consistent drives are needed before treating the Eagles as a convincing top-tier team.

Tennessee Titans

Designated home · Power Rank #30

Consensus average: 30.50. Tennessee needs basic offensive rhythm after a difficult opener. Longer possessions and more defensive resistance are necessary to make the next game genuinely competitive.

12POINTS

Expert pick: Tampa Bay Buccaneers

Sun Sep 20 - 1:00 PM ET

Tampa Bay Buccaneers favored by 8.5 points (reference line)

Cleveland Browns

Designated away · Power Rank #31

Consensus average: 31.25. Cleveland cannot count on its defense to cover offensive limitations yet. Both units need a substantial response before the outlook moves beyond early-season concern.

Tampa Bay Buccaneers

Designated home · Power Rank #18

Consensus average: 18.25. Tampa Bay moved the ball but undermined itself with turnovers. Protecting possessions could produce a quick rebound, especially if the defense sustains its second-half improvement.

11POINTS

Expert pick: Seattle Seahawks

Sun Sep 20 - 4:25 PM ET

Seattle Seahawks favored by 4.5 points (reference line)

Seattle Seahawks

Designated away · Power Rank #1

Consensus average: 1.25. Defense gives Seattle a strong foundation despite quarterback uncertainty. Week 2 will test whether the offense can contribute without relying on another late rescue.

Arizona Cardinals

Designated home · Power Rank #24

Consensus average: 23.75. Arizona's defense offered encouragement. Backing it up against Seattle would establish that the improved outlook extends beyond one upset.

10POINTS

Expert pick: Los Angeles Rams

Mon Sep 21 - 8:15 PM ET

Los Angeles Rams favored by 7 points (reference line)

New York Giants

Designated away · Power Rank #16

Consensus average: 16.00. The Giants showed a more physical, controlled identity under John Harbaugh. Repeating that execution against another opponent matters more than one encouraging opening win.

Los Angeles Rams

Designated home · Power Rank #3

Consensus average: 5.00. The Rams still have enough talent to rebound. Garrett's absence and a demanding early schedule make a sharper, more coordinated performance urgent.

9POINTS

Expert pick: Los Angeles Chargers

Sun Sep 20 - 4:05 PM ET

Los Angeles Chargers favored by 7 points (reference line)

Las Vegas Raiders

Designated away · Power Rank #28

Consensus average: 27.50. Las Vegas handled a favorable opening matchup. Sustaining progress without Brock Bowers is the next challenge, with stronger opponents providing a clearer test.

Los Angeles Chargers

Designated home · Power Rank #22

Consensus average: 21.50. Protection concerns and defensive transition cloud the Chargers' outlook. Better passing timing is achievable, but the response must include improvements beyond Justin Herbert.

8POINTS

Expert pick: Chicago Bears

Sun Sep 20 - 1:00 PM ET

Chicago Bears favored by 5.5 points (reference line)

Minnesota Vikings

Designated away · Power Rank #17

Consensus average: 17.00. Minnesota's comeback and Jefferson's production offer encouragement. Quarterback uncertainty complicates the outlook, making stable offensive execution the next test rather than assuming another dramatic recovery.

Chicago Bears

Designated home · Power Rank #7

Consensus average: 7.00. Chicago's offense offers considerable scoring upside. A defense that allowed 37 points must improve before an explosive opener becomes convincing evidence of a complete contender.

7POINTS

Expert pick: Buffalo Bills

Thu Sep 17 - 8:15 PM ET

Buffalo Bills favored by 4.5 points (reference line)

Detroit Lions

Designated away · Power Rank #13

Consensus average: 12.00. Detroit survived despite exposed pass-defense weaknesses. Better coverage and communication are essential while the secondary works through injuries; offensive production alone leaves little margin.

Buffalo Bills

Designated home · Power Rank #2

Consensus average: 4.00. Josh Allen keeps Buffalo dangerous against anyone. The next step is defensive consistency, so winning does not require another high-scoring finish.

6POINTS

Expert pick: New England Patriots

Sun Sep 20 - 1:00 PM ET

New England Patriots favored by 5.5 points (reference line)

Pittsburgh Steelers

Designated away · Power Rank #21

Consensus average: 19.75. Pittsburgh can lean on defensive playmakers, but offensive scoring remains a concern. More sustained drives would reduce dependence on game-changing plays from the defense.

New England Patriots

Designated home · Power Rank #14

Consensus average: 14.00. New England's first priority is reducing costly quarterback mistakes. A steadier passing performance would make its narrow opening loss look more correctable than defining.

5POINTS

Expert pick: Green Bay Packers

Sun Sep 20 - 1:00 PM ET

Green Bay Packers favored by 4.5 points (reference line)

Green Bay Packers

Designated away · Power Rank #19

Consensus average: 19.00. Green Bay needs to finish games while navigating important absences. Cleaner late-game execution would help prevent another promising start from unraveling.

New York Jets

Designated home · Power Rank #27

Consensus average: 26.50. The Jets looked organized on both sides. Repeating that against stronger opposition is necessary before one win justifies a major reassessment.

4POINTS

Expert pick: Dallas Cowboys

Sun Sep 20 - 4:25 PM ET

Dallas Cowboys favored by 3.5 points (reference line)

Washington Commanders

Designated away · Power Rank #23

Consensus average: 22.75. Washington's protection held up better than feared. Reducing mental errors and sustaining offensive execution could turn a competitive opening loss into a more encouraging start.

Dallas Cowboys

Designated home · Power Rank #15

Consensus average: 15.00. Dallas has time to recover, but preseason optimism needs on-field evidence. Winning physical matchups and producing timely stops are central to the Week 2 response.

3POINTS

Expert pick: Carolina Panthers

Sun Sep 20 - 1:00 PM ET

Carolina Panthers favored by 1.5 points (reference line)

Carolina Panthers

Designated away · Power Rank #25

Consensus average: 25.25. Bryce Young gives Carolina something to build on. Defensive repairs are urgent; offensive progress cannot compensate for repeated breakdowns.

Atlanta Falcons

Designated home · Power Rank #29

Consensus average: 28.50. Bijan Robinson provides a dependable offensive focal point. Quarterback uncertainty limits Atlanta's outlook until the passing game can contribute enough to keep defenses honest.

2POINTS

Expert pick: Houston Texans

Sun Sep 20 - 1:00 PM ET

Houston Texans favored by 3 points (reference line)

Cincinnati Bengals

Designated away · Power Rank #8

Consensus average: 7.50. Defensive takeaways changed Cincinnati's opener. Week 2 should reveal whether the improvement extends to routine stops rather than depending on another turnover-heavy afternoon.

Houston Texans

Designated home · Power Rank #12

Consensus average: 11.75. Houston remains competitive, but quarterback ball security demands attention. Finishing possessions cleanly is the clearest route from a close loss to a Week 2 rebound.

1POINTS

Expert pick: Denver Broncos

Sun Sep 20 - 4:05 PM ET

Denver Broncos favored by 2.5 points (reference line)

Jacksonville Jaguars

Designated away · Power Rank #6

Consensus average: 7.00. Jacksonville handled an overmatched opponent convincingly. The roster looks competitive, but stronger opposition will offer a better measure of its championship potential.

Denver Broncos

Designated home · Power Rank #10

Consensus average: 9.25. Denver retains considerable defensive upside despite a poor opener. Cleaner tackling and a more functional offense are immediate priorities before confidence returns.

The Odds Lines are for reference only as they may have changed since publishing.